SIMILAC PRO-ADVANCE ® STEP 1

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SIMILAC PRO-ADVANCE ® STEP 1

with 2'-FL oligosaccharide / DHA- and ARA-fortified

For use as a breast milk substitute in infants who are not exclusively breastfed. For oral or tube feeding use.

AVAILABILITY

FEATURES

• Our most advanced formula with 2’-FL. *
• 2'-FL * is structurally identical to 2'-FL human milk oligosaccharide (HMO), 1 the most abundant HMO found in the breast milk of most mothers. 2
• Addition of 2'-FL * to infant formula may help support the development and regulation of the formula-fed baby's immune response to be closer to that of breastfed infants. 3,†
• DHA, the most abundant Omega-3 fatty acid in brain and eyes. 4
• Lutein, an antioxidant found in breast milk and concentrated in the infant brain and eyes. 5,6,7 Recent studies show that lutein may have a role in visual and cognitive development. 8
• Vitamin E, a dietary antioxidant that protects fats in body tissues from oxidation. 9 Similac Pro-Advance® uses natural vitamin E, ‡ the most abundant form found in breast milk and in the infant brain. 10,11
• Non-GMO. §
• Easy to digest. ¶
• Gluten-free.
• Kosher.
• Halal.

PRECAUTIONS

• Not for parenteral use.

* Not derived from human milk.

1 Weichert S et al. Nutr Res 2013;33(10):831-8.

† Breast milk is best for babies, contains many immune factors not available in infant formula, and its use is recommended for as long as possible during infancy.

2 Castanys-Muñoz E et al. Nutr Rev 2013;71(12):773-89.

‡ RRR-alpha-tocopherol, the most bioactive form of vitamin E.

3 Goehring KC, et al. J Nutr. 2016;146(12):2559-2566.

§ Ingredients not genetically engineered.

4 Calder PC. Ann Nutr Metab 2016;69(Suppl. 1):8-21.

¶ Similar to other infant formulas.

5 Zimmer JP, et al. Clin Ophtalmol. 2007;1:25-35.

6 Krinsky NI, et al. Annu Rev Nutr. 2003;23:171-201.

7 Vishwanathan R, et al. JPGN. 2014;59(5):659-65.

8 Johnson EJ. Nutr Rev. 2014;72(9):605-12.

9 Canadian Food Inspection Agency: Health Claims – Nutrient Function Claims. Last modified on 2019-10-31. [Accessed online on 2023-11-14]

10 Kuchan MJ, et al. Curr Dev Nutr. 2018;2:nzy055

11 Kuchan MJ, et al. Br J Nutr. 2016;116(1):126-31.

PREPARATION

• Directions for Use: Your baby’s health depends on carefully following these directions. Proper hygiene, preparation, mixing, and storage are important when using infant formula. Failure to follow these directions could result in severe harm. Use as directed by your health care professional. Wash hands thoroughly with soap and water.
  1. Sterilize equipment: Place washed bottles, nipples, rings, caps, and all preparation equipment in boiling water and keep at a rolling boil for 2 minutes. Sterilize water: In another pot, boil water at a rolling boil for 2 minutes. Cool to room temperature prior to mixing.
  2. Prepare formula using enclosed scoop - see Mixing Guide. Return dry scoop to container.
  3. Cap bottle; shake well; attach nipple.

Once feeding begins, use within 1 hour or discard.

Mixing Guide

Cooled sterilized water

Unpacked Level Scoop(s)

Storage

• Once mixed, refrigerate bottles immediately; use within 24 hours. Once feeding begins, use within 1 hour or discard.

NUTRITION

Unflavored Powder

• Similac Pro-Advance® Step 1; 584 g can; 6/case
• Similac Pro-Advance® Step 1; 859 g can; 6/case

Serving size: 100 g (Powder)

• Value

• Product Characteristics

• AT STANDARD DILUTION

• Caloric Density (Cal/mL)
• 0.68

• Protein (% of total energy)
• 8.2

• Protein Source
• Dry or evaporated skim milk, whey protein concentrate, whey protein hydrolysate

• Fat (% of total energy)
• 48.8

• Omega-6:Omega-3 Ratio
• 9.7:1

• MCT oil (% of total fats)
• 0

• Fat Source
• High oleic safflower oil, soy oil, coconut oil, M. alpina oil, Schizochytrium sp. oil, soy lecithin

• Carbohydrate (% of total energy)
• 43.0

• Carbohydrate Source
• Lactose, fructooligosaccharides, 2’-fucosyllactose

• Total Cal:g Nitrogen Ratio
• 309:1

• Nonprotein Cal:g Nitrogen Ratio
• 284:1

• Water (g/L)
• 904

• Osmolality (mOsm/kg water)
• 303

• Renal Solute Load (mOsm/L)
• 97

• Recommended Tube Size for Gravity/Pump Feeding (Fr)
• N/A

Unflavored Powder

• Similac Pro-Advance® Step 1; 584 g can; 6/case
• Similac Pro-Advance® Step 1; 859 g can; 6/case

Serving size: 100 mL (at standard dilution)

• Value

• Product Characteristics

• AT STANDARD DILUTION

• Caloric Density (Cal/mL)
• 0.68

• Protein (% of total energy)
• 8.2

• Protein Source
• Dry or evaporated skim milk, whey protein concentrate, whey protein hydrolysate

• Fat (% of total energy)
• 48.8

• Omega-6:Omega-3 Ratio
• 9.7:1

• MCT oil (% of total fats)
• 0

• Fat Source
• High oleic safflower oil, soy oil, coconut oil, M. alpina oil, Schizochytrium sp. oil, soy lecithin

• Carbohydrate (% of total energy)
• 43.0

• Carbohydrate Source
• Lactose, fructooligosaccharides, 2’-fucosyllactose

• Total Cal:g Nitrogen Ratio
• 309:1

• Nonprotein Cal:g Nitrogen Ratio
• 284:1

• Water (g/L)
• 904

• Osmolality (mOsm/kg water)
• 303

• Renal Solute Load (mOsm/L)
• 97

• Recommended Tube Size for Gravity/Pump Feeding (Fr)
• N/A

Unflavored Powder

• Similac Pro-Advance® Step 1; 584 g can; 6/case
• Similac Pro-Advance® Step 1; 859 g can; 6/case

Serving size: 100 Cal

• Value

• Product Characteristics

• AT STANDARD DILUTION

• Caloric Density (Cal/mL)
• 0.68

• Protein (% of total energy)
• 8.2

• Protein Source
• Dry or evaporated skim milk, whey protein concentrate, whey protein hydrolysate

• Fat (% of total energy)
• 48.8

• Omega-6:Omega-3 Ratio
• 9.7:1

• MCT oil (% of total fats)
• 0

• Fat Source
• High oleic safflower oil, soy oil, coconut oil, M. alpina oil, Schizochytrium sp. oil, soy lecithin

• Carbohydrate (% of total energy)
• 43.0

• Carbohydrate Source
• Lactose, fructooligosaccharides, 2’-fucosyllactose

• Total Cal:g Nitrogen Ratio
• 309:1

• Nonprotein Cal:g Nitrogen Ratio
• 284:1

• Water (g/L)
• 904

• Osmolality (mOsm/kg water)
• 303

• Renal Solute Load (mOsm/L)
• 97

• Recommended Tube Size for Gravity/Pump Feeding (Fr)
• N/A

INGREDIENTS

Unflavored Powder

• Similac Pro-Advance® Step 1; 584 g can; 6/case
• Similac Pro-Advance® Step 1; 859 g can; 6/case

Lactose, Dry or Evaporated Skim Milk, High Oleic Safflower Oil, Whey Protein Concentrate, Soy Oil, Coconut Oil, Fructooligosaccharides, Whey Protein Hydrolysate, M. Alpina Oil (A Source Of ARA), 2'-Fucosyllactose (2'-FL), Schizochytrium Sp. Oil (A Source of DHA), Soy Lecithin, L-Tryptophan, Taurine, M-Inositol, Cytidine 5'-Monophosphate, Ascorbyl Palmitate, Disodium Guanosine 5'-Monophosphate, Disodium Uridine 5'-Monophosphate, Adenosine 5'-Monophosphate, Mixed Tocopherols, L-Carnitine, Lutein, MINERALS (Calcium Carbonate, Potassium Citrate, Potassium Hydroxide, Magnesium Chloride, Sodium Chloride, Ferrous Sulphate, Tricalcium Phosphate, Zinc Sulphate, Copper Sulphate, Manganese Sulphate, Potassium Iodide, Sodium Selenite), VITAMINS (Ascorbic Acid, Choline Bitartrate, D-Alpha-Tocopheryl Acetate, Niacinamide, Calcium D-Pantothenate, Vitamin A Palmitate, Thiamine Chloride Hydrochloride, Riboflavin, Pyridoxine Hydrochloride, Folic Acid, Beta-Carotene, Phylloquinone, Vitamin D3, D-Biotin, and Cyanocobalamin).

Contains: Milk, Soy.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.